Character: Xenomorph (main character)
Origin: Alien (movie, 1979)

 

Character: Starfleet Captain (main character)
Origin: Star Trek (television, 1966 onwards)

 

Character: Agent Smith (main character)
Origin: The Matrix Reloaded/Revolutions (movie, 2003)

 

Character: V (main character)
Origin: V for Vendetta (movie, 2005)

 

Character: Benny (main/support character)
Origin: The LEGO Movie (movie, 2014)